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Re: Alcohol and Anti-depressants.

Posted by undopaminergic on July 6, 2008, at 9:07:15

In reply to Alcohol and Anti-depressants., posted by MattSanz on July 5, 2008, at 8:38:41

> Hello,
> I'm currently taking Zoloft and Abilify for my depression and I was wondering, does anyone know what the consequences are of using illegal drugs (cocaine, MDMA, etc.) or alcohol while taking anti-depressants? I was wondering in terms of whether taking illegal drugs or drinking alcohol will have an actual effect on how well the Zoloft will work. Thanks!

I think Abilify might antagonise the effects of cocaine to some extent, whereas Zoloft may slightly enhance them (additive serotoning and dopamine reuptake inhibition). Higher doses of Zoloft would be likely to block the effects of MDMA if taken prior to it, due to blockade of the serotonin transporter which is required for the serotonin-releasing effects of MDMA. On the other hand, if Zoloft is taken after MDMA, it may possibly prolong its effects somewhat. Zoloft and other serotonin reuptake inhibitors are also known to protect against the toxicity of MDMA to serotonergic neurons if taken before or soon enough after MDMA.




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