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Re: Failed on Nardil ....What next???

Posted by Crotale on July 4, 2008, at 9:18:50

In reply to Re: Failed on Nardil ....What next???, posted by undopaminergic on June 30, 2008, at 0:13:35

Hi...I had the same sort of problems with Nardil pooping out & causing weight gain.

Trying Parnate again is a thought...or how about selegiline? You could mix it with a selective NE reuptake inhibitor. e.g., Strattera, or one of the TCAs like desipramine, nortriptyline, amoxapine, or maprotiline; avoid imipramine, amitriptyline, doxepin, or (especially) clomipramine; also not any of the SSRIs or mixed-reuptake-inhibitors like Effexor, or newer drugs like Remeron.

> > -Try Electroshock Therapy?
> Too dangerous in my opinion, but even if it would be effective without erasing your memory, you would presumably still need antidepressants in order to prevent relapse into depression.

I've been having ECT for a while and I haven't had any memory problems. There's also TMS, if you have access to it.

> You may wish to try Marplan first for comparison, and then decide whether to stay on it or go back on Parnate.

Marplan, being a hydrazine-type MAOI like Nardil, tends to cause the same sort of weight gain type side effects.

> > Wellbutrin
> > Ritalin
> These are good choices for augmenting MAOIs, and are likely to be safe, but caution is still advised, especially in the beginning of treatment.
> > Dexedrine
> This drug has more potential for dangerous interactions with MAOIs than the other stimulants, but when it is carefully added at a low dose and titrated in small increments, it can be very safe and highly effective.

Adderall is also okay to try with caution. Another stimulant that you can use safely (safer than amphetamine or methylphenidate) with MAOIs is Provigil. (I use this one on occasion.)

> > Serzone
> This one has been used safely with MAOIs, and may be particularly useful for MAOI-induced insomnia.

Ummm....Are you sure about that? I know trazodone has been combined safely with MAOIs (although personally I found that like most sleeping pills, I built up tolerance to it after a few days) but I'm not sure about Serzone.

> Most opioids are also safe. Buprenorphine is especially suitable.

True; I take buprenorphine with Parnate, and have for a number of years. I would suggest starting at a low dose, say 0.15 or 0.2mg, as it can cause nausea and vomiting.
Avoid Ultram with MAOIs.

Good luck....




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