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Tianeptine + Desipramine

Posted by satsumas on July 3, 2008, at 13:35:29

In reply to Re: That's very interesting, considering... WickedGirl, posted by Molybdenum on July 3, 2008, at 6:06:57

great thread. I wanted to try tianeptine but my doctor suggested desipramine first as he hadn't had much experience with tianeptine and said that a well known bipolar researcher at Stanford wasn't all that enthused about tianeptine's efficacy in BP depression.

i'm now in the process of tapering up on desipramine (at 75, dr says eventually i should be at 125 or 150) and going down from effexor (at 112.5, coming off from 300, where I finally felt good for the first time in 2 years, but had slight hypomania and strong cravings and apathy).

Where I am right now is feeling pretty blah, but with a bit more energy (assume that's desipramine) but i don't feel the "okayness" and lack of obsessive thoughts, and optimism and excitement and capcity for pleasure that I did when effexor was at 300 (which i'm assuming was from the serotonin effects).

MY QUESTION is: Is it OK to take desipramine with tianeptine? My Dr. hinted that they both are effectively doing the "same thing" with tianeptine increasing norep via its decrease of serotonin, but i'm not so sure about that. Does anyone have any experience with this combo?

I feel like I definitely need something for serotonin, but don't want to go the MAOI route, and i am sick of the SSRIs, and in fact any serotonin reuptake mechanism (even a serotonin based TCA).





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