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Re: Gerovital H3 ??? MAOI fanboys ? ;)

Posted by undopaminergic on June 27, 2008, at 20:25:01

In reply to Gerovital H3 ??? MAOI fanboys ? ;), posted by Marty on June 26, 2008, at 14:02:23

Procaine is an interesting drug. It is the first synthetic analogue of the first effective local anaesthetic cocaine. It consists of the acetylcholine precursor dimethylaminoethanol (DMAE) joined by an ester bond with the vitamin-B-like substance para-aminobenzoic acid (PABA). Procaine itself - like all potent 'caine local anaesthetics - blocks sodium channels, but it also has weak dopamine reuptake-inhibiting properties as well as modest and reversible MAO-inhibitory potential. However, the relevance of the properties of procaine itself as opposed to its metabolites is questionable because it is rapidly broken down into its constituents (DMAE and PABA) within minutes - much more rapidly than even the relatively short-lived cocaine.




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