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Re: Opiates, oxycodone

Posted by undopaminergic on June 25, 2008, at 2:59:58

In reply to Opiates, oxycodone, posted by cactus on June 22, 2008, at 4:07:10

Buprenorphine rarely produces a high (never, in my experience - not even with stimulants), and may have a reduced tendency for inducing tolerance. Moreover, it's a kappa-opioid receptor antagonist, which reduces the incidence of many unpleasant effects. It also has a milder withdrawal syndrome than other opiates.

Combining opioids with NMDA-antagonists is a useful strategy for preventing or at least attenuating tolerance. The most useful options for NMDA-antagonists are memantine and dextromethorphan; amantadine might be an option.

Opioid rotation strategies may also be effective in the long run. In short, because cross-tolerance is often incomplete, switching to a different opioid drug may restore efficacy as one is failing.




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