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Re: mnilnacipran now (2007) » SLS

Posted by bleauberry on May 15, 2008, at 17:20:26

In reply to Re: mnilnacipran now (2007) » bleauberry, posted by SLS on May 15, 2008, at 5:45:03

Hi Scott,
I don't think the urinary stoppage is due to organ enlargement. It happens too fast (24 hours) for that to be the case. I believe the urinary hesitancy/stoppage/urgency is caused by NE constricting muscles down there. Flomax works by blocking NE effects on the peripheral alpha-1 receptors in bladder, prostate, and peripheral body. I'm not sure if it works in the CNS or not. Others have mentioned behanacol in the past. One person here a few months back was on desipramine with urinary probs like me and said 2mg flomax completely fixed it. Since I already have flomax, but never tried it, that would be the place to start, with bethanacol as an alternative option if flomax has bad effects.


> > I had to stop because of one of its less frequent side effects...urinary hesitancy. I constricted my bladder/prostate so bad I could barely pee it was dangerous and mighty uncomfortable. The manufacturer's info says that side effect can be countered with Flomax, so I am thinking about that.
>
> How do you know the urinary hesitancy is due to increased organ size rather than an autonomic side effect? For something autonomic, you might want to try bethanechol (Urecholine). It is a parasympathomimetic ACh muscarinic agonist.
>
>
> - Scott


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URL: http://www.dr-bob.org/babble/20080510/msgs/829287.html