Posted by okydoky on May 8, 2008, at 10:46:02
In reply to Re: Best AD For Pain, posted by bulldog2 on May 2, 2008, at 18:24:00
There is substantial literature for instance for one particular pain (Interstitial Cystitis bladder) that tricylics help. Cymbalta now has research showing it is no better than placebo for this while initially great hope was held out for this treatment in particular.
Intuitively I would suggest that any AD that has benefits for the depression itself would have a good potential to ease at the very least someones tolerance for pain and their ability to deal with it. From the standpoint even that a lot of people are more active when not depressed and moving around physically, lubricates the joints and massages internal muscles and organs, increasing blood flow to all. Also being active could release more endorphins which could help with all the above. Obviously what I have stated here I have not backed up with any literature as over many years I cannot remember all that I have read and have a very poor memory. It would be interesting to read if anyone here would post some of it. I do not have the patience to try and look up a lot of information at least today.No doubt there is a lot of information about particular AD's stating that it would help with pain. For instance "imipramine"
http://www.cnn.com/HEALTH/library/PN/00044.html
A small article about exercise and pain management: http://www.cnn.com/HEALTH/library/AR/00017.html
A bit more in depth about different antidepressants and pain and depression , somatic pain: http://www.hopkins-arthritis.org/patient-corner/disease-management/depression.html
Lyrica is being marketed for fibromyalgia now. It was originally marketed for diabetic neuropathy pain besides its other uses. It is similar to Neurontin. Some find it works better for pain than Neurontin. I used it for a specific type of pain associated with urinary frequency, a Neuropathic or Visceral pain, and it provided complete relief. I do not understand the underlying chemicals and how they relate to pain but interestingly my experience with Lyrica while completely ameliorating one type of pain I still had arthritic pain or somatic pain and a different type of bladder pain in my bladder that resolves itself with oxycontin or other narcotics. The arthritic pain is helped by other drugs such as Naproxen.One other mention depressed people have a tendency for poor posture or stooped posture which contributes to or causes muscular skeletal pain. When some relief is gotten form the depression the posture tends to improve and hence less pain.
poster:okydoky
thread:826596
URL: http://www.dr-bob.org/babble/20080430/msgs/827918.html