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Re: Budeprion XL

Posted by undopaminergic on April 28, 2008, at 23:54:07

In reply to Re: Budeprion XL » undopaminergic, posted by Racer on April 28, 2008, at 8:52:48

> >
> > I strongly disagree with that. It is very common with many drugs to get the strongest response initially, with progressively declining effects in the following days or weeks.
>
> Can we say that this pattern is common *IN YOUR EXPERIENCE,* since it's far from common overall, and absolutely nothing like my own experience.
>

Perhaps "very common" was an exaggeration that is true only for some people, such as myself, but the development of tolerance and loss of efficacy after initial response to a drug is not at all unusual - especially not in the case of rapidly acting drugs, although it should be noted that different effects of a drug may differ in their persistence upon chronic treatment - this applies to both benefits and adverse effects.

> I'm sorry if that's been happening to you with medications, and I'm very sorry if you're not getting much benefit from the medications you've tried -- but that is not a pattern I've read about very often around here,
>

As far as I've seen, "not getting much benefit" from many or most medications tested seems to be a frequent issue "around here".

> > In my (somewhat unfortunate) experience, a couple of months is an extremely long time for a drug to work, and indeed, I've yet to experience it.
>
> A couple of months is not a long time for a drug to work. There are many people -- probably *most* of the people who take antidepressants, although not necessarily those who post here -- who take the same antidepressant for years, with good results. It's tragic you haven't experienced that, yet, but your experience may not be as typical as you seem to believe.
>

Note that in this case I did say "in my experience", and I even suggested that my experience may be somewhat unfortunate, so whence do you get the idea that I believe it's typical? Besides, it should be seen in light of the context in which it was said - it was directly in response to your comment:

"if you're only getting a couple of months of benefit, my guess would be that you're getting mostly a placebo effect ... doesn't sound like enough time to lose robust benefits."

> > Of course, there are drugs that tend to work slowly (if at all), in which case efficacy may improve over the first weeks or months, and last for months or years. However, bupropion is not one of these.
>
> It has been for me.

Are you saying it took a long time (weeks to months) to reach efficacy? I have the impression that bupropion generally has a fast onset of action, and that many people notice the effects after the first dose.

> I have taken buproprion for close to four years now, with good results. I like my Wellbutrin, it is my good and trusted friend, and has been very loyal to me. I can't say that it's ever been 100% effective -- but I can say that it's close enough, considering the benign side effect profile. That is, my experience of the side effect profile.
>

It's great that you've found it dependable in the long term, but it doesn't imply that anyone else's response to the drug must be placebo only because it doesn't last.


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