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Re: ADVICE Lamictal and addaerall or provigal???

Posted by undopaminergic on April 15, 2008, at 0:57:34

In reply to Re: ADVICE Lamictal and addaerall or provigal???, posted by dbc on April 14, 2008, at 14:59:18

> > hi, i'm just curious-- why do you ask about cocaine? is cocaine similar in structure/mode of action/reaction to adderall or provigil?
> > thanks!
> > cb
>
> Psychiatrists refer to ritalin/methylphenidate as "kiddie cocaine" because it shares similar neurological effects. Thus if you responded favoribly to cocaine you may respond better to ritalin than amphetamine (adderal).
>

Methylphenidate, cocaine and modafinil are all dopamine reuptake inhibitors. It's likely that oral cocaine, as a sustained release formulation, would be quite effective for treating ADHD without inducing a "high". Meanwhile, it has been demonstrated (in experienced cocaine users) that intravenous methylphenidate is indistinguishable from cocaine (modafinil isn't soluble, so it can't be injected).

There are still notable differences between the drugs, of course.

Amphetamine (Adderall), however, differs quite substantially. It releases dopamine (DA), whereas the others only block the reuptake of DA that was already released. Therefore, amphetamine can effect much higher increases in extracellular DA than any of the others, and can be useful where the others lack efficacy. Another effect that distinguishes amphetamine from the others is that its long-term abuse is associated with pathological changes in several radiological markers of dopaminergic function - this can be visualised with brain imaging techniques.


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URL: http://www.dr-bob.org/babble/20080412/msgs/823375.html