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Re: Schizophrenia - adding Amisulpride to Clozapin

Posted by Quintal on March 29, 2008, at 7:23:57

In reply to Schizophrenia - adding Amisulpride to Clozapine, posted by pretty_paints on March 25, 2008, at 8:52:34

I'm currently taking amisulpride 50mg for depression/anhedonia, and it is certainly lesss sedating than the other antipsychotics I've taken. I think Clozapine is supposed to be the most sedating. I don't think amisulpride has much (if any?) H1 antagonism compared to the others, and in addittion at low doses it tends to have an activating effect. Although it does sometimes make me feel a little sleepy for an hour or so after a dose, it's nothing like the leaden sedation you get with drugs like Zyprexa or Seroquel. It sometimes makes me a little jittery.

You'd probably need to take higher doses than 50mg to control the positive symptoms of schizophrenia though. Has the pdoc suggested a dose? I was transferred from 10mg Zyprexa to 200mg amisulpride when I was being treated for psychosis in hospital, but that is still a relatively low dose. I'm not sure why the pdoc didn't give me at least 300mg. Maybe he was just playing devil's advocate to see if I relapsed? Anyway, even at 200mg I didn't feel tired or sedated like with other APs. I hope this works out for you.

Q


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