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Re: Nardil: My Experience Thus Far.... » tecknohed

Posted by Phoenix1 on January 7, 2008, at 19:00:36

In reply to Re: Nardil: My Experience Thus Far.... » tapiocamonk, posted by tecknohed on January 6, 2008, at 23:05:46

> > Question though: I've heard that it takes more Nardil to do the trick since the reformulation by Pfizer; were you on the old formulation or the new and do you think it matters?
>
> Depends. People who have used the old Nardil before & then switch/return to the new Nardil nearly always say that its not the same and they need more of it. However, for people who have never taken Nardil before the new stuff seems to work as good as, and at the same doses as old Nardil. If that makes any sense.
> I myself live in the UK & as far as I know Nardil here has never changed, at least in recent years. UK's Nardil pills are orange with no markings & need to be refridgerated.
>
> > That's very interesting. I hadn't heard any of that before about GABA and the short half life.
>
> Its Nardils main metabolite. Its called PEH (phenylethylidenehydrazine) & elevates levels of GABA in the caudate-putamen and nucleus accumbens. Dont ask me what that means - I just copied from a web site. LOL. But its well known that Nardil increases GABA. When I was on low dose Klonopin (1.5mg) & wished to stop it for a while my pdoc said there was no need to taper as my Nardil would take care of the GABA. He was right.
> I think the half-life is 3-6hrs.
>
> > Question: do you think spreading the dose will have any positive or negative effect on daytime sedation and possible insomnia? I think I can deal with the daytime sedation, but I dealt with MAOI insomnia for years on Parnate and am definitely not looking forward to a return of that.
>
> I've never taken Parnate but from what I've heard its NOTHING like Nardil. Some people complain of insomnia with Nardil but usually only at the beginning. I think spreading the dose is always best to reduce side effects, even take 15mg 4 x day if you can. I'd say sedation will be much more likely than insomnia with Nardil, especially when you raise the dose (which many people need to do eventually) & are taking 30mg 3 x day. Thats when you'll want to add something activating. But hopefully that wont happen. I'm not trying to scare you, just being honest :)
>
> > If I had to choose, I would take anorgasmia over low libido any day of the week. I feel like if the Nardil kicks in and I can start behaving like a normal person, getting involved socially and maybe even having a girlfriend and having a sex drive on top of that, I'll just deal with the anorgasmia when it comes up.
>
> Anorgasmia is horrid. Trust me. I never lost my libido with Nardil though. But just trying to cum will sap all your energy. But like I said before there ARE remedies so take note of them.
>
> > Thanks so much for your advice. I really hope everything that you say will prove true and that Nardil will flip that switch with my personality.
>
> ME TOO :)

Was there ever consensus on whether getting Nardil enteric coated (by a compounding pharmacy or using Plasminplus) increased the effects/bioavailability?

Phoenix1


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URL: http://www.dr-bob.org/babble/20080105/msgs/804901.html