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Re: STAR*D confirmed what patients already knew » linkadge

Posted by Larry Hoover on January 6, 2008, at 14:15:01

In reply to Re: STAR*D confirmed what patients already knew, posted by linkadge on January 5, 2008, at 15:24:47

> Well, strong response to a placebo might have helped support the finding that pretty much all choices are essentially equivilant.

Placebo response has been shown to be poorly maintained over time.
http://www.ncbi.nlm.nih.gov/pubmed/17854252
"The relapse rate in placebo responders was 24.1%, whereas the relapse rate in antidepressant responders was 7.4%"

The drug fluoxetine was associated with broader changes in brain function than seen in placebo responders.
http://ajp.psychiatryonline.org/cgi/content/full/159/5/728
"...while comparable brain changes were seen with both drug and placebo administration, drug response was not merely the same as the placebo effect, as active fluoxetine treatment was associated with additional and unique changes in the brainstem, striatum, and hippocampus."

Moreover, decreases in prefrontal cortical cordance were associated with reduction in depressive symptoms in a medication (fluoxetine) group, whereas an increase in cordance was associated with placebo response.
http://ajp.psychiatryonline.org/cgi/content/full/163/8/1426

Whatever placebo response is, it is not the same as drug response.

Lar

 

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poster:Larry Hoover thread:804126
URL: http://www.dr-bob.org/babble/20080105/msgs/804652.html