Posted by cumulative on November 29, 2007, at 19:52:11
Suppose I was going to trial the dopamine agonist piribedil, but was concerned that it may have too much activity at D2 as compared to D1. Functionally, in the worst case the effect may be to increase hyperactive, hedonic, impulsive behavior without giving much help with what I really need/want -- attention, focus, verbal fluency. Prefrontal dopamine might be more involved with D1. So I dunno, especially if I do end up wanting to block some of the adrenergic effects that trivastal has, with clonidine (preferably guanfacine if I can source it), both at nighttime for sleep and even in the morning to curb said effects. Constant norepinephrine stimulation is no way for this poster to live.
Happily, some of the people who have trialed this drug do describe sharpened focus and concentration -- but again, this may be related to the extra adrenergic stimulation piribedil causes (unlike most dopamine agonists).
So, I know all this is getting quite hypothetical, but supposing I wanted to stimulate D1...? What kind of things would I look at? Unfortunately, the obvious answer which is the classic psychostimulants is out of the question. 300mg/daily amineptine might be good too, but it's far, far out of my price range (which has already been breached) to get both trivastal and that much amineptine.
All the real here, I'm looking at you.
Low-dose amantadine? Hydergine? Pergolide? Is anyone in the world making dihydrexidine?
poster:cumulative
thread:797696
URL: http://www.dr-bob.org/babble/20071125/msgs/797696.html