Posted by Questionmark on November 15, 2007, at 3:26:36
In reply to Re: Prozac in particular » War-Face, posted by circusboy on November 13, 2007, at 15:15:02
Yeah, Prozac acts on the 5-HT2C receptor (as well), i'm pretty sure. But remember part of what could contribute to its anxiogenic and more or less stimulating type of effects is that its metabolite... duloxetine, i believe (as opposed to Prozac/fluoxetine)... is a NRI-- and one with a significantly long half-life, if i'm not mistaken.
Also, do you know, does it pretty much sound like overall consensus here that Zoloft does have qualities different enough than other SSRIs in a way that feels like a dopamine reuptake inhibiting effect? That would be interesting because, yeah, the experts seem to think that its effect on the DA transporter would be negligible in terms of subjective effects.
Also, does Strattera really act on the kappa opioid receptor? I never heard that. That's really interesting if so.
> > I found Prozac, on the other hand, to be extremely motivating (probably from NE boosting properties), although after prolonged use, it did leave me feeling dumb and forgetful and tired, in a way similar to the well-articulated cycle of SSRI use above.
> Wanted to chime in and say I've had very similar experiences with Prozac. Pretty good in the short term, then the not-insignificant cognitive deficits start to move in. Also, the Prozac-induced anxiety (5-HT2C agonism? I can't remember which receptor subtype) starts to overwhelm the positive effects as well, and I become a nervous idiot in social situations.
> I was prescribed methylphenidate to help with the concentration issues, but it took a very high dose (40 - 60 mg/day) which left me in irritable withdrawal every night. Once the Prozac was out of my system, I could have a very productive day on only 10 mg methylphenidate.
> As a sort of aside... I know most of us believe this here, but it's worth repeating: the secondary affinities of "selective" drugs like the SSRIs are highly significant. Prozac at the NE transporter, Zoloft at the DA transporter, (Strattera at the kappa opiate receptor...not a SSRI, but still), Lexapro doing...something sleepy... all of these things are /supposed/ to be clinically insignificant, but those of us who have tried these drugs know they're not.