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One Deplin® 7.5mg tablet is bioequivalent to ... » Zyprexa

Posted by Ron Hill on October 30, 2007, at 0:48:11

In reply to Re: Is DEPLIN the real deal?? » Ron Hill, posted by Zyprexa on October 28, 2007, at 12:33:29

Hello Zyprexa,

How's it goin'? I hope you're doing well.

> I hate to tell you this but it’s not 75 times higher in the report, but 7 times.

Nope. What I said is completely true:
One Deplin® 7.5mg tablet is bioequivalent to taking seventy-five 800 mcg folic acid pills.

Actually, I blocked, copied, and pasted this statement verbatim from the Deplin website. The claim is located on the lower half of this web page:

http://www.deplin.com/DeplinFacts,VsFolicAcid

In my previous e-mail on this subject, I chose to post the reference document, (Ref. 17), instead of the Deplin website page because the reference document contains the actual data backing up the claim.

No offense intended, but one of your errors is in not accounting for the fact that the study medication consisted of a 5 mg oral dose of folic acid, and a 5 mg oral dose of 6[R,S] 5-MTHF. The "7 times" factor that you refer to is specifically and exclusively for these particular dosages (actually dosage ratio) used in the study. However, these dosages in the study are very different from the dosages referred to in the statement; "One Deplin® 7.5mg tablet is bioequivalent to taking seventy-five 800 mcg folic acid."

In this latter case, the oral dosages are 800 mcg folic acid (= 0.8 mg folic acid) and 7.5 mg of 6[S] 5-MTHF (i.e.; L-methylfolate, a.k.a. Deplin). From the data in the study, it is possible to calculate that it takes 75 tablets of 800 mcg folic acid to equal the bioequivalence of one 7.5 mg Deplin tablet.

Further, you did not account for the fact that the study uses a single dose of orally administered 6[R,S] 5-MTHF, a commercially available racemic mixture of the two diastereoisomers of 5-MTHF. However, the administration of Deplin is void of the R isomer. In other words, Deplin is the S isomer, 6[S] 5-MTHF (L-methylfolate), and it does not contain any of the R isomer, 6[R] 5-MTHF.

When I ran the calculations, I came up with 70 tablets of 800 mcg folic acid. I can't find my error, but I've spent too much time already on this trivial issue. Time to move on -- I got bigger fish to fry.

> Not sure what it was saying about cardiovascular risk. But looked like folic acid may be safer. i would have to read it more.

No, the unknown risk, discussed in the last paragraph of the document, is with regard to the accumulation of the R isomer in the human body when 6[R,S] 5-MTHF is administered. However, this is a non-issue for the administration of Deplin because it does not contain any of the R isomer.

Nice talking to you, Zyprexa. Be well, my friend.

-- Ron

Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)

600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin


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poster:Ron Hill thread:791850
URL: http://www.dr-bob.org/babble/20071027/msgs/792286.html