Posted by Ron Hill on October 29, 2007, at 16:35:11
In reply to Re: Is DEPLIN the real deal?? » Ron Hill, posted by King of Nothing on October 29, 2007, at 10:29:41
> Thanks, and congratulations!!!
Thank you, King. Time will tell if it lasts, but it feels right.
Do you plan to try Deplin http://www.deplin.com ? Deplin is not unique; there are other similar Rx products on the market. For example, CerefolinNAC http://www.cerefolinnac.com/index.php , and Metanx http://www.metanx.com . All three contain various amounts of Metafolin http://www.metafolin.com .
Further, Cerefolin and Metanx contain, respectively, two and three vitamins, blended with the Metafolin. Deplin, on the other hand, contains only Metafolin.
Metafolin is the trademark name for Merck's patented product. Metafolin is patented for the production process used to produce the food grade L-methylfolate. A company called Eprova, fully owned by Merck, invented the process and manufactures Metafolin. The tricky part of the production process is separating the bioactive 6[S] 5-MTHF (another name for L-methylfolate) isomer from the non-bioactive and highly undesirable 6[R] 5-MTHF isomer.
OTC products contain relatively small amounts of Metafolin (e.g.; 0.8 mg/tablet), whereas one tablet of Deplin, for example, contains 7.5 mg. On a per milligram basis of Metafolin, the OTC products are VERY VERY expensive compared to the Rx product Deplin.
Further, as I understand it, Merck is actively in the process of eliminating the OTC's because Merck wants products that contain Metafolin to be available Rx only. To make this happen, all Merck would need to do is politely refuse to sell Metafolin to OTC manufacturers. Currently, Metafolin is the only game in town when it comes to food grade L-methylfolate.
But, I read recently that Merck has made a special deal with HSfighters http://www.hsfighters.com . However, as you know just because it is written on the web does not guarantee that it is true.
TMI (too much information). Sorry if I rambled. If you try Deplin or one of the other similar products, let us know how your trial goes.
Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)
600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin