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Re: About switching to sertraline (Zoloft)

Posted by psychobot5000 on October 26, 2007, at 14:07:37

In reply to About switching to sertraline (Zoloft) deniseuk190466, posted by rgb on October 20, 2007, at 14:33:07

> Hello Denise,
> you mention the possibility of switching to sertraline. This might be worth a try since sertraline is a minor (but not tooo minor) dopamine reuptake inhibitor.

I respectfully disagree concerning sertraline's dopamine reuptake - my understanding is that is it very small indeed. However, I wouldn't be surprised if sertraline were better than paroxetine for attentiveness, because paroxetine is anticholinergic, which can be good for mood, but bad for thinking. ...anyway, a friend of mine taking sertraline has great difficulty with sleepiness (though possibly a little less than with lexapro), so beware.

The answer some have suggested to me (on this board and from docs) to prevent sleepiness on SSRIs (which I think was one of your problems?) was either to switch to prozac or luvox, which would apparently be somewhat more energizing (for many people, at least), or else adding provigil, which my friend found works very well to knockout sleepiness, but is expensive.

Switching to an activating tricyclic like desipramine or nortriptyline does seem like a good idea to me.





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