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Re: relation to seleginine????

Posted by psychobot5000 on October 21, 2007, at 21:15:08

In reply to Re: relation to seleginine????, posted by KayeBaby on October 17, 2007, at 17:09:35

I have posted on this subject before, though my figures included guesswork.

Nevertheless, the way it was described to me by someone who was integrally involved with the development of the EMSAM patch is as follows:

EMSAM and selegiline are the same substance. However, you would need a very high dosage of oral selegiline (perhaps 80mg taken orally) to get the same blood-levels of selegiline as you get from a 6mg EMSAM patch worn for 24 hours. The reason is that the patch has a much higher efficiency at getting the drug into your bloodstream. This leads to another difference: much of the selegiline you take orally passes through the liver on its way into the bloodstream. The liver processes much of the dose into other active chemicals: amphetamines, mostly. So with an oral dose, you get the impurity of those amphetamine metabolites also.

In sum, as I understand it, the patch gives higher blood levels of the parent drug, with much lower blood levels of amphetamine metabolites, so there is a modest practical difference between them, though they're the same drug.




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