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Re: Ok, Fluoxetine is the most stimulating SSRI...

Posted by Amigan on September 16, 2007, at 12:52:55

In reply to Re: Ok, Fluoxetine is the most stimulating SSRI..., posted by linkadge on September 16, 2007, at 12:19:02

Thank you for your replies.
It's strange that both of you are suggesting an action on the reuptake of norepinephrine, because i have browsed many sites (like rxlist, wikipedie) and non mentions of a significant NE reuptake inhibition. It's not that i don't believe you. (LOL) Perhaps it's something that is not well documented.

> Fluoxetine does have some affinity for norepinephrine and dopamine reuptake pumps. Less than sertraline but still present.

Exactly. LESS than sertaline.
Furthermore, i have read many studies suggesting that fluoxetine , among other SSRIs, can even cause a decrease on the amount of dopamine in the synapses. According to these studies, some rare advert effects like akathisia and EPS are attributed to this action.

> Some of fluoxetine's metabolites also have effects on other neurotransmitter systems.

Ok.

> Fluoxetine is also a 5-ht2c antagonist. 5-ht2c antagonists have locomotor stimulant like properties.

I see. There so many different 5-ht receptors. It's difficult for me to keep track of them all. :D


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poster:Amigan thread:783231
URL: http://www.dr-bob.org/babble/20070911/msgs/783239.html