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Re: SSRI's gateway drugs? » rskontos

Posted by Larry Hoover on August 27, 2007, at 20:28:39

In reply to Re: SSRI's gateway drugs?, posted by rskontos on August 27, 2007, at 19:35:50

> Lar, do you believe everything the drug manufacturer's literature say when they only do trials for 12 weeks presently.

Of course not. I'm a chemist, specializing in environmental toxicology. I interpret the chemistry of a substance in terms of their effects on organisms. The octanol/water partition coefficient for duloxetine, and the rate of enzymatic degradation, clearly show that this substance cannot accumulate in tissues.

> My neurologist is the one that says the drug can live in the tissues with in the the body.

No, it can't. Water solubility and osmosis are not going to let that happen.

> You are referring to shelf live. Yes cymbalta has a short shelf life which is why you need to taper off of it when coming off.

Half life. t½.

The published half-life is 8-17 hours, mean 12. Even at 17 hours, after five half lives (just over 3 1/2 days), there is 1/32 (i.e. 1/ 2^5) of the original blood concentration remaining.

> But during my taper which was hell, I had brain zaps, and more things going on which wound me up in the hospital.

Yes, there is a substantial withdrawal syndrome associated with duloxetine.

> Also, my neurologist has several patients all that had seizures due to AD's. Cymbalta being the worst. You might know your stuff but not all of it.

I didn't say it doesn't happen. I said it was uncommon. I would suspect that a neurologist such as yours is perhaps the most likely to "catch" such cases, on referral from other doctors.

> Pardon me but I have been on three different boards and this isn't the first time I have heard what I have been talking about. But I will leave you guys to your stuff. I thought I would find support here but instead I have found people that believe everything Lilly spits out as truth.

I don't mind your holding different opinions than mine. Debate shouldn't be seen as being unsupportive. I would hope you'd keep an open mind.

> Beware of the drug companies it is money to them. Look at their protocol for getting off the drug. It doesn't work.

What protocol is that?

> There are several boards out there for withdrawal from AD's and it is de-toxong. Don't bit your tongue on my account.

Okay.

> Wellbrutrin is not helpful for panic attacks.

Wellbutrin holds the dubious honour of being the psych drug most likely to induce seizure. They had to revise downwards the maximum dose to get the expected seizure rate down below 2%. Duloxetine is less than 0.1%, in comparison.

> The homework the doctor didn't do is prescribing cymbalta for panic attacks versus lexapro and with seizure history that would have been the appropriate protocol.

Okay.

> Sorry you think I don't know what I am talking about but I do.

I suggested there were minor problems within a body of truth.

> But I will shut up for now. Good luck to everyone on this board, I will find another.

Please don't leave on my account.

Lar

 

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