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Re: Norfluoxetine » Klavot

Posted by Larry Hoover on August 8, 2007, at 9:23:15

In reply to Norfluoxetine, posted by Klavot on August 8, 2007, at 8:04:27

> Is the following claim correct?
>
> "Norfluoxetine is the only active metabolite of fuoxetine. Therefore the antidepressant effect of fluoxetine is entirely due to norfluoxetine."
>
> Klavot

I don't know where you found this quotation, but it's a misinterpretation of the pharmacokinetic data. Prozac is supplied as a racemic mixture of R- and S- enantiomers, both of which are roughly equal in antidepressant effect. Of all the metabolites, S-norfluoxetine is also considered to be of similar antidepressant effect, and it has a longer half-life than its parent. R-norfluoxetine is both less active, and better eliminated, so it is of little consequence.

Poor metabolizers at 2D6 produce less S-norfluoxetine, but because the parent is active, it is considered to be of little therapeutic consequence.

Lar

 

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poster:Larry Hoover thread:774750
URL: http://www.dr-bob.org/babble/20070808/msgs/774766.html