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info pertaining to lamotrigine poop out

Posted by linkadge on July 15, 2007, at 17:17:00

Hi, I have been trying to read on some of the possable mechanisms of lamotrigine.

According to this study, lamotrigine increases serotonin levels and dopamine acutely in rats, but they returned to normal after about 3 weeks.

Could this pertain to the propensity of lamotrigine to give a boost that doesn't last for long?

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http://www.nature.com/bjp/journal/v142/n1/full/0705737a.html
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In chronic experiments, rats were dialysed after 2, 4, 7, 14 and 21 days of LTG treatment (5 mg kg-1, twice daily). During this period a progressively different response to the drug was seen. After 2 days, basal extracellular 5-HT was significantly greater in treated rats than control rats. This effect persisted up to 14 days, but by 21 days 5-HT levels had returned to control values. 5-HIAA levels were unaltered and there was no effect of LTG on veratridine or K+ stimulated 5-HT release.
Similarly, DA concentrations significantly increased after 2–7 days of LTG treatment, but returned and remained at basal values thereafter. During the treatment period LTG had no effect on extracellular DOPAC, but HVA followed a similar pattern to its parent transmitter. As with 5-HT, at no time point did LTG have any effect on stimulated DA release.
These neurochemical findings observed in these experiments are considered in relation to the use of LTG in bipolar disorder.

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Linkadge



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poster:linkadge thread:769760
URL: http://www.dr-bob.org/babble/20070710/msgs/769760.html