Posted by revaaron on July 8, 2007, at 17:45:08
In reply to Re: Xyrem (GHB) for depression and anxiety, posted by shasling on July 6, 2007, at 12:32:31
> You'd be diong it all day long and dependency/
> addiction is a very real danger.
Don't get me wrong, there is a real abuse potential, and if you're taking it daily you will become physically addicted to it, even if you're not "abusing it."
However, I disagree with the idea that you would be dosing on it all day long. I've only talked to a couple folks who were using Xyrem for depression (and one for depression+AD/HD+chronic fatigue), but at least with the people I've spoken with, it was the dopamine rebound/"dawn" effect that was helping them, not the GABAergic intoxication. It was something they took before bed, slept during the intoxicated phase, and woke up with the dopamine rebound, and had the effect of increased dopamine through the day.
There is always phenibut, but it'd only be useful occasionally. That is, phenibut has a very long acting, but not as intoxicating, GABAergic effect. For me, in causes most of the good symptoms of GHB intoxication without the intoxication, at least at the doses I've had of both. Those were- anti-anxiety (more effective than any benzo, in my body at least), big increase in sociability, a lift in mood (though not euphoria), marked relaxation. I didn't feel any desire to sleep or mental impairment.
Alas, phenibut has some peculiarities that make it not sustainable. Folks can't take it every day without developing a tolerance to it quickly. This tolerance isn't the usual tolerance, like with opiates and GHB where using over long periods requires a gradual ramp up of dosage to
keep the same level of effectiveness. Phenibut tolerance starts within days and even at huge doses, after a couple weeks might be ineffective. Even folks using it dilligently twice a week report tolerance over time.
Perhaps it might be worthwhile to look into some of the other GABAergics in the same family of GHB/phenibut, like Neurotonin (sp?) and Pregabalin (Lyrica). There are a few others I can't think of off the top of my head.