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Re: Gepirone has not dissapeared!

Posted by Maximus on July 2, 2007, at 16:15:35

In reply to Gepirone has not dissapeared!, posted by Maria3667 on July 2, 2007, at 14:55:38

> No! In fact, the manufacturer has refiled an application for it with the FDA last May.
>
> This novel anti-depressant which acts as an agonist on the 5HT-1a-receptor and an antagonist on the N-2a-receptor is reputed to have much less side effects than the currently available SSRI's.
>
> It's also reputed to be pro-sexual for FEMALES (hurray, our own Viagra at last???).

I don't know if Gepirone is a potent Alpha 2 antagonist? On paper it looks good but in a day to day usage alpha 2 antagonists produce rage and/or irritability on a lot of patients.

Moreover several studies found that gepirone increases plasma corticosterone levels, which is "generally" bad.

Don't want to sound pessimistic but i would not hold my breathe for this stuff. Though its action on 5TH1a receptors could be beneficial for some...


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URL: http://www.dr-bob.org/babble/20070630/msgs/767206.html