Posted by Jedi on June 20, 2007, at 2:11:57
In reply to Re: Going Off Parnate, next drug - your insight?, posted by sophia04 on June 20, 2007, at 0:29:37
I think most everyone who takes a MAOI ends up taking another med for the associated insomnia. I started with trazodone, have used diphenhydramine, and found Seroquel in doses of 12.5 to 25mg the best for me.
Atypical depression is actually more common than the name implies. Symptoms include reactive mood, overeating, oversleeping, and rejection sensitivity, among others. There is some debate over the actual defining symptoms.
Also, there has been some research done which suggests that by combining a TCA with a MAOI, there is actually less chance of a hypertensive tyramine reaction. I never tested this personally.
Best of luck,
Columbia atypical depression. A subgroup of depressives with better response to MAOI than to tricyclic antidepressants or placebo.Quitkin FM, Stewart JW, McGrath PJ, Tricamo E, Rabkin JG, Ocepek-Welikson K, Nunes E, Harrison W, Klein DF.
New York State Psychiatric Institute, NY.
We summarise a series of studies using a MAOI to help establish the validity of a subgroup of depressives referred to as atypical depressives. Patients with reactive mood meeting DSM-III criteria for depressive illness who had associated atypical features (which include hyperphagia, hypersomnolence, leaden paralysis, and rejection sensitivity) were randomised to imipramine, phenelzine and placebo. Non-responders were crossed over, and in all there were over 400 patient trials. Phenelzine consistently was found to be superior to imipramine. Only in trials which included patients lacking atypical, vegetative symptoms was imipramine found to equal phenelzine. We conclude that the researcher and the clinician should consider the relevance of the atypical depressive syndrome.
PMID: 8217065 [PubMed - indexed for MEDLINE]
Atypical Depression - What's in a name?