Posted by steel on June 14, 2007, at 11:57:23
I remeber being on Nardil,and no longer tolerating the trial,which was short lived,i popped 3 parnate,no washout.Yess i know this is horrendously dangerous,at the time i was deep in gloom i dont think i knew what dangerous meant.
Anyway those 3 parnate opened my brain like the sun through church windows,i mean BANG i was in total bliss,just felt totaly correct and balanced.
I aside also never took much on the washout period of maoi-maoi since the actions are mostly similiar,however that is just my opinion.
I since tried the two at the same time and could not repeat the response,BUT found this abstract discussing if i read correct that they actualy in trial used parnate/and or deprenyl in pre treatment for Nardil due to nardils strong gaba affect which might not be welcomed by all,and might be the differance between people who like the med and dont.Any way here is the link and snip.
GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline.
Todd KG, Baker GB.
Department of Psychiatry, University of Alberta, Mackenzie Health Sciences Centre, Edmonton, Canada.
The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by pretreatment with the MAO inhibitor tranylcypromine (TCP), suggesting that the GABA-elevating effect is largely the result of a metabolite of PLZ formed by MAO. In the present report, rats were pretreated with the nonselective MAO inhibitor TCP, the MAO-A inhibitor clorgyline and the MAO-B inhibitor (-)-deprenyl: at the doses used, clorgyline and (-)-deprenyl caused selective inhibition of MAO-A and MAO-B, respectively. Both TCP and (-)-deprenyl caused a greater reduction in the GABA-elevating action of PLZ than did clorgyline, suggesting that MAO-B is more important than MAO-A in the formation of the active metabolite of PLZ. The results also suggest that an effect other than, or in addition to, inhibition of GABA transaminase by the metabolite may be important in the GABA-elevating action.