Posted by linkadge on June 13, 2007, at 14:39:11
In reply to Re: Depression change in brain anatomy » linkadge, posted by FredPotter on June 10, 2007, at 21:29:14
It always works both ways of course. Depression can cause pathological brain chemistry just as pathological brain chemistry can affect depression.
One of the individuals I respect the most in the field is Dr. Manjii. Apparently, while mood stabilizers don't usually have that much acute antidepressant effect, they do have ability to affect cellular survival beyond the capability of antidepressants. Perhaps adding a low dose of a mood stabilizer may have more effect on the long term outcome of depression?
Antidepressants may poop out in that they might exhaust the underlying circutry. Theres only so much energy at the cellular level. Just as in parkinsons, there may be depletions of intracellular or mitochondrial energy. Maybe depressed people are really "insane in the membrane"
A healthy lifestype would undoubtedly have a positive effect on brain placticity, but depression can negativly affect the desire to live a healthy lifestyle.
I don't have all the answers, but it seems to me that the people who do the best in the long run don't put too many eggs in one basket, and don't rely too much on any one therapy(?)
Probably best to combat it from all possable angles, diet, exercise, therapy/social interaction, meds etc.
For instance, according to this study, social iscolation selectivly decreases BDNF protein in animals.
This is interesting, since a separate animal study showing that prozac increases BDNF, failed to tell the reader that BDNF increased in any animal that had been handled, and not just prozac treated animals.
Anyhow, I am getting off base.