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Re: selegiline/emsam details » psychobot5000

Posted by Quintal on June 9, 2007, at 1:15:38

In reply to selegiline/emsam details » Quintal, posted by psychobot5000 on June 9, 2007, at 0:37:44

Thank you for the information psychobot, I had a feeling it had something to do with the bypassing the gut/liver metabolism. The selegiline still exerts its antidepressant effect as an MAOI though, but presumably it's more selective and effective at inhibiting the MAO in the brain when delivered this way. This isn't necessarily true for all drugs delivered transdermally though. I guess it depends on how they're affected by first-pass metabolism and whether they have any active metabolites etc? Will look up amitriptyline. Ketamine is a practical option for anyone who can get access to it.

Q


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