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Grapefruit and Zoloft experiment

Posted by bravohr98 on June 8, 2007, at 6:06:57

I have been taking zoloft before for a few months for depression with medium success.

A week ago I decided Ill give it another try; maybe on a higher dosage. I was taking 50mg before.

First time I took it I felt it work within a few days, especially for social anxiety. But this time I was on it for a week and felt like it was not working at all. I know it takes quite a while for SSRI to start working so I decided to sick with 50mg for few weeks before I up the dose.

Yesterday I made myself a cup of grapefruit juice. I drank only half and then I remebered that I read somewhere that it can have interaction with some medication so I threw away other half of the juice.

Well, I was minding my own business and then all of a sudden I realized lift in my depression. It was very subtile at first but as the time went by I could feel the effect getting stronger.

for the next 5-6 hours I actually felt like 30-40% lift in my depression witch is remarkably good since I have been having depression and dysthymia for years now.

After 6 hours or so the effect was gradually lost but I was really amazed what effect it had on me.

Today I researched grapefruit a little more and it seems that it inhibits enzymes responsible for drug metabolism. Also found a research page about grapefriut and sertraline. It seems to inhibit sertraline degradation in liver.

I know its very dangerous to take grapefruit with drugs because of its drug metabolism effects, and it can raise drug level in blood to high; 300-400% for some drugs - but it really helps.

I think this is something to look into a bit more and it may have some therapeutical importance.

Maybe it could be used in small amounts when ADs stop working. Or maybe even trying a smaller dosages ADs with grapefruit.

I will definitely try it again and post the results, but this time ill try a smaller dose and see how its works.


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