Posted by Squiggles on June 4, 2007, at 20:20:09
In reply to Re: Mirtazapine, posted by linkadge on June 4, 2007, at 19:54:13
> >I was looking at one of Dr. Nemeroff's books and >his colleague's (a guide), and this drug >Mirtazpine (a TCA) looks really good.
>
> Remeron isn't a TCA. Not sure of the structure, but it is not reltated to traditional TCA's.
>
> >It has very low anticholinergic effects, thus >good for the heart,
>
> I don't know if one can make this conclusion. The cardiac effects of TCA's are not due to their anticholinergic activity. Remeron can sometimes increase blood pressure and heart rate like other alpha-2 antagonists (yohimbine etc)
>
> >very little hypotension, and easy to tolerate >all-around, with one adverse reaction which >stops when the drug is stopped.
>
> Well, that does sound like a nice (drug book) summary. Remeron has different side effects, but not necessarily less burdonsome. It can be very sedating. It can cause irritability (REM rage) it can also increase the appetite significantly.
>
> >It looks like a drug that might be good for >seniors too.
>
> Well, I don't know.
>
>
> Linkadge
>>
Right, it's a tetracyclic - the only one FDA approved. Actually, it is the *only* drug my
friend who has major depressive disorder took, that made her look alive and happy, EVER in the serial drugging of about 20 ADs. Unfortunately, it made her sleepy so it was terminated-- seems to me that with such a stellar performance this drug could have been adjuncted with a stimulant.As for the appetite, i wonder if it is not like lithium which makes you eat a lot and is sometimes used on anorexics. With a drug that has such unique "clean" attributes, you'd think clinicians would be knocking themselves out trying to clean up the edges.
Squiggles
http://www.sciencedaily.com/releases/2007/01/070101113033.htm
poster:Squiggles
thread:761234
URL: http://www.dr-bob.org/babble/20070604/msgs/761242.html