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Re: What have I got to lose by having ECT

Posted by rvanson on June 3, 2007, at 1:03:51

In reply to Re: What have I got to lose by having ECT, posted by Deniseuk190466 on June 2, 2007, at 16:31:38

> Rvanson,
>
> Thanks for the suggestions.
>
> I've heard that mannerix is an MAOI and that it has very weak antidepressant effects. I've already tried Nardil (supposed to be stronger) and it didn't work and I'm loathe to do another switch from lexapro to another MAOI.
>
> As to Solian, istn't that Amilsupride? I do take Zyprexa now and again (another anti-psychotic) wouldn't Amilsupride have the same affect as Zyprexa?


You are correct that Solian and Amisulprid(e) are the identical medicine/chemical. In lower doses, Solian can help boost or aid the effects of anti-depressants and the adhedonia conditions.

In the higher dose range it acts as an anti-psychotic medication much like Zyprexa and brings on drowsiness for me and others.

I have tried Zyprexa in the past and found it much too sedating to tolerate, even at the lowest dose ranges.

As for Mannerix (Moclobemide) it is indeed a MAOI but is a "reversible" one. It acts on epinephrine (adrenaline), norepinephrine (noradrenaline), serotonin, and lastly dopamine.

Unlike the standard MAOIs, Nardil and Parnate, the side effects of Mannerix do not normally include cardiovascular complications (hypertension) with encephalopathy, liver toxicity or hyperthermia after consumption of a restricted medication or food.

I have found that in combination with a small dose of certain SSRI's that this combination of Mannerix/SSRI works very well for me, for a time.

Unfortunately, the effects don't last for as long as I have hoped, and I feel somewhat edgy with the extra norepinephrine in my system, but for a while I feel almost "normal" again after 25 years of feeling like an outcast of society, due to adhedonia.

Perhaps for you or some others here, you may have a better, longer lasting response to such a combination of medications.

Its a shame that these medications are not available through US doctors, as the FDA has not approved them for use here.


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poster:rvanson thread:760391
URL: http://www.dr-bob.org/babble/20070524/msgs/760987.html