Posted by Klavot on May 29, 2007, at 12:26:44
In reply to Re: Effexor and dopamine, posted by cornfedboy on May 29, 2007, at 9:33:12
I seem to recall that Zoloft inhibits serotonin reuptake by 80 % at 50 mg / day and 100 % at 200 mg / day. Check out Sheldon Preskorn's website for many interesting articles on this:
As I recall, he made the point that it is not worthwhile quadrupling the dose of Zoloft and thereby "quadrupling" side-effects for a mere 20 % extra benefit.
There is an article on Effexor answering some of your questions at
http://www.preskorn.com/columns/9911.html
Bear in mind that the interpretation of "binding affinities" etc. is tricky and subject to many paramaters. If I understand correctly, greater binding affinity does not necessarily mean more potency.
For what it's worth, I personally think that dopamine is overrated. Read the Wikipedia article at
http://en.wikipedia.org/wiki/Dopamine
They make the point that dopamine may actually regulate desire rather than motivation. It so happens that desire is a strong motivator.
Klavot
poster:Klavot
thread:760068
URL: http://www.dr-bob.org/babble/20070524/msgs/760176.html