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Effexor and dopamine

Posted by cornfedboy on May 28, 2007, at 21:01:51

I just can't seem to get a straight answer on this one, or find hard data on the Internet.

Fact1: At low doses (37.5 to 150) venlafaxine works basically like an SSRI.

Fact2: At higher doses (150? to 300?) it's effect on serotonin plateaus and the norepinephrine activity kicks in.

But what about dopamine? Everywhere I look I'm told that Effexor "weakly" affects dopamine reuptake. How weak? And at what dose? Some say that the dopaminergic effects kick in around 300; others say 375; still others say 600.

Is there any hard data on this?

BTW, I'm on 300 mg of Effexor XR. I feel fine. But low motivation has always been an issue for me, hence the interest in venlafaxine's action on dopamine.

Thanks!

Cornfedboy


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poster:cornfedboy thread:760068
URL: http://www.dr-bob.org/babble/20070524/msgs/760068.html