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Re: Tianeptine + Nicergoline = Remission (For Me!) » linkadge

Posted by Quintal on April 22, 2007, at 18:04:23

In reply to Re: Tianeptine + Nicergoline = Remission (For Me!), posted by linkadge on April 22, 2007, at 17:51:14

Nicergoline is an ergoloid mesylate derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.

It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy.

It is marketed under the trade name Sermion.
http://en.wikipedia.org/wiki/Nicergoline
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Properties

Sermion (nicergoline) is a vasoactive pharmaceutical product, synthesized in Farmitalia research laboratories, with alpha-adrenolytic action to activate the brain's metabolism. Sermion (nicergoline) acts on different levels:

On the cerebral level, it prompts a lowering of vascular resistance, an increase in arterial flow and the use of oxygen and glucose. In terms of lung circulation, it lowers vascular resistance. With regard to limb circulation, it brings about an increase in the flow, particularly evident in those patients with insufficient irrigation due to functional arteriopathies.

Studies carried out in vitro and in vivo, both experimental and on human beings, have shown that Sermion (nicergoline) inhibits platelet aggregation. Sermion (nicergoline) has proved to be effective in hospital use, regulating and improving brain disorders caused by metabolic-vascular insufficiency and alterations derived from insufficient arterial irrigation in the limbs. When the therapeutic dosage is administered, Sermion (nicergoline) does not affect arterial tension. In the case of patients suffering from hypertension, it may induce a gradual lowering of tension.

This pharmaceutical product does not induce vomiting.

Indications

Acute and chronic cerebral metabolic-vascular disorders (cerebral arteriosclerosis, thrombosis and cerebral embolism, transitory cerebral ischaemia). Acute and chronic peripheral metabolic-vascular disorders (organic and functional arteriopathies of the limbs), Raynaud's disease and other syndromes caused by altered peripheral irrigation.

Migraines of vascular origin

Coadjutant therapy in clinical situations accompanied by platelet hyper-aggregability, arterial tension

Corio-retinal vascular disorders: retinal thromboses, diabetic retinopathy, macular degeneration and retinal angiosclerosis Oto-vestibular problems of a vascular nature: dizziness, auditory hallucinations, hypoacusis.

Dosage

By mouth: 5-10 mg (1-2 tablets or 20-40 drops) 3 times daily at regular intervals over prolonged periods of time. To facilitate absorption, take this medicine between meals.

The dosage and length of treatment are to be decided by your doctor. At times, the therapeutic effects of Sermion (nicergoline), both subjective and objective, are not immediately noticeable, but will be noted after a certain period of treatment.
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That's about all I can get on it. I'm wondering what the "alpha-adrenolytic action to activate the brain's metabolism" bit means? I've read elsewhere that nicergoline is an alpha-adrenergic neurone blocker, but I don't fully understand what this means to be honest. Does that mean it's an 'alpha-blocker'?

Q


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URL: http://www.dr-bob.org/babble/20070419/msgs/752496.html