Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: RLS, Akathisia + Dopamine D-2 receptors? Larry Hoover

Posted by cache-monkey on April 12, 2007, at 20:43:23

In reply to Re: RLS, Akathisia + Dopamine D-2 receptors? cache-monkey, posted by Larry Hoover on April 12, 2007, at 9:04:13

Larry,

Thanks for your input, although I must admit I'm not sure what to make of it. I mean, I get what you're saying, but the functional import of it is not so clear. If you have a little more time to amplify, I would appreciate it.

I guess what I'm concerned about is dopamine supersensitivity, which is thought to be the basis of tardive phenomena. Philip Seeman's been doing a lot of work showing that the conversion of D-2 receptors to a supersensitized high-affinity state happens with chronic D-2 blockade, ethanol withdrawal, and a whole variety of brain injuries. I suppose a simple, although non-specific, test would be to see how I respond to a dose of ritalin or adderall. Increased agitation would be an inicator of supersensitization.

Thanks again,
cache-monkey


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:cache-monkey thread:747867
URL: http://www.dr-bob.org/babble/20070407/msgs/749399.html