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Re: RLS, Akathisia + Dopamine D-2 receptors? Larry Hoover

Posted by cache-monkey on April 12, 2007, at 20:43:23

In reply to Re: RLS, Akathisia + Dopamine D-2 receptors? cache-monkey, posted by Larry Hoover on April 12, 2007, at 9:04:13


Thanks for your input, although I must admit I'm not sure what to make of it. I mean, I get what you're saying, but the functional import of it is not so clear. If you have a little more time to amplify, I would appreciate it.

I guess what I'm concerned about is dopamine supersensitivity, which is thought to be the basis of tardive phenomena. Philip Seeman's been doing a lot of work showing that the conversion of D-2 receptors to a supersensitized high-affinity state happens with chronic D-2 blockade, ethanol withdrawal, and a whole variety of brain injuries. I suppose a simple, although non-specific, test would be to see how I respond to a dose of ritalin or adderall. Increased agitation would be an inicator of supersensitization.

Thanks again,




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