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Re: Paradoxical effects of tricyclics? Squiggles

Posted by Larry Hoover on April 8, 2007, at 10:04:59

In reply to Paradoxical effects of tricyclics?, posted by Squiggles on April 7, 2007, at 15:11:02

> Does anyone know if it is possible to
> develop paradoxical effects with the tricyclics?

Yes, it is.

> I know that there is a self-limited reaction of this
> nature with benzos, but i have never heard of it with other drugs. The symptom of interest is
> hypersomnia (circadian cycle, same time).. could
> be something like the brand (weaker for example)
> or something else of course. How would one go about diagnosing this? Exclusion is nice but try to get someone with enough time to do that these days.
> Thank you for reading.
> Squiggles

What you're calling exclusion (sic) is the only way, if I'm guessing correctly about what you meant. It's called a dechallenge/rechallenge trial. You taper off the suspect drug, then retitrate to the old dose. If the offending symptoms disappear, then reappear, you have presumptive evidence for the idiosyncratic reaction.





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