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thyroid and meds Phillipa

Posted by Larry Hoover on April 8, 2007, at 9:44:57

In reply to Re: Betrayed and put into what type of condition? Larry Hoover, posted by Phillipa on April 5, 2007, at 19:26:35

> Larry I take 2000mg daily of ester C. And a plant based multi. So the selenium isn't adequate?

I can't tell, from here. Only you know have the info about what you swallow. How much selenium is in the multi? The "official" UL for selenium intake is 400 mcg/day, so rest assured that I'm not pushing any absurd intake level on you. It's just that your thyroid is under incredible stress because of autoimmune activation, and you can ease its functioning with selenium intake. Selenium is even more essential than iodine, in one respect, as the enzymes that manipulate the iodine all are structurally dependent on selenium.

> I must be having these storms nightly as it's on going with nightmares.

I was suggesting acute episodes of thyroiditis as an explanation for the occasional severe symptoms which sent you to the emergency room, not the day-to-day sleep disturbances. Have I misunderstood? Most nights, it's the same thing over and over, but once in a while, you have a real horrible physical reaction, right?

> When I picked up the two serzone pills the printout said no motrin or nsaids.

I don't understand that. I read the entire drug monograph, and found no similar warning. Ibuprofen is a substrate for 2C9, so it is unaffected by Serzone (i.e. no metabolic interaction).

> Also cautioned about the benzos the pdoc said only xanax he was mistaken as it says all benzos and sleep meds.

There's strong evidence that Xanax metabolism is directly affected by Serzone, with lesser evidence of a similar interaction with other classes of benzos. That's metabolic interaction. A separate issue is what is called synergism, where two drugs have similar functional effects. The sedation from one drug can add substantially to that of another, even though they might work by different mechanisms. Someone combining these drugs needs to be aware that they might become literally impaired by the meds.

> Is lunesta included in this category of what they give no examples of sleep meds?

Yes, because of potential additive or synergistic functional effects.

> I have been in all day on the computer. Whooped. So I haven't gotten selenium yet. Love Jan ps also still on the incredible dose of valium he said to take. I've wondered if it could be a paradoxical reaction to valium too as I take over the course of the night 30mg. Just for a few hours of sleep. No deep sleep apparently.

The monograph for Valium gives dosing of up to 40 mg/day. That's what you're getting, right?

I know how incredibly difficult this would be, but your unusual (lack of) response to the high dosing might indicate that your body has developed some adaptation to block this chronic exposure. If so, the only option is to taper off completely, and then wait for everything to settle down. Like I just went through.

Lar

 

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