Posted by falconman on April 7, 2007, at 3:34:38
In reply to Re: tianepyine + ssri/snri » falconman, posted by psychobot5000 on April 6, 2007, at 20:59:04
> > Hi,
> > yeah but in terms of sertonergic activity only , do you think they would?
> >
> > > Tianeptine + remeron would probably not cancel, since remeron has noradrenergic activity as well.
> > >
> > > Linkadge> > Thanks, that helps alot. I always thought remeron was a re-uptake inhibitor. It makes sense that its not cause it actually does work a little.
>
> They shouldn't cancel each other's serotonergic activity, no.
>
> Tianeptine works via encouraging reuptake inhibition, but Remeron acts specifically at receptors, at clinical dosages. It does not have any net effect on extrasynaptic serotonin levels--it sticks to blockading 5ht 2a, 2c and 5ht3 receptors. So it's unlikely to block tianeptine's presumed mechanism of action.
>
> Tianeptine, in turn, does not have any (known) effects on serotonin receptors, so it probably wouldn't interfere with Remeron's receptor antagonism.
>
> It's hard to say how they'd interact in practice. It seems, theoretically, like a sensible thing to try, though, and safe.
>
poster:falconman
thread:746891
URL: http://www.dr-bob.org/babble/20070402/msgs/747787.html