Posted by Larry Hoover on March 27, 2007, at 5:58:26
In reply to Re: Cozaar Helps! Can You Believe it? » Pluto, posted by saturn on March 25, 2007, at 9:08:20
> Hi Pluto...Saturn here. :)
> > Interesting isn't it?
>
> Very...I've recently been thinking about the possible role of drugs that work primarily outside the brain.
>
> Though I really don't know how to evaluate statements like:
>
> "The antidepressant potential of the angiotensin antagonist losartan was assessed using the mouse forced swim test."Well, maybe this would help?
http://en.wikipedia.org/wiki/Forced_swimming_testA very crude measure, by any stretch, but it is a behavioural test which is thought to measure the tendency of rodents to display learned despair, something we attribute to humans in a depressed state. Alternatively, one could argue that normal mice can figure out there's no point trying to swim out of this particular situation, whereas the drugged ones haven't yet clued in.
I guess it's fair to say that antidepressant *potential* is seen, as known antidepressant agents do demonstrate sustained swimming effects in rodents.
> I don't discount the possibility of its antidepressant effects. Glad to hear of your results! And thanks for posting this.
>
> Peace...Saturn.I'm glad to hear of this serendipitous benefit, also.
Lar
poster:Larry Hoover
thread:744013
URL: http://www.dr-bob.org/babble/20070327/msgs/744552.html