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Re: Tianeptine and Zoloft - Advice Needed » Quintal

Posted by naughtypuppy on March 14, 2007, at 10:23:01

In reply to Tianeptine and Zoloft - Advice Needed, posted by Quintal on March 14, 2007, at 0:57:37

> As you all know, I've been taking the Coaxil (Czech) brand of tianeptine for over a week now and I am not impressed thus far. It is proving to be effective in modifying/normalizing my response to stress - almost ran over a pheasant yesterday and instead of reacting by shaking for half an hour afterward (or with the fist-waving, hollering rage/angst of benzos) I was completely calm, composed and serene.
>
> The Problem
> ------------
>
> Is that it isn't helping my anxiety much, agoraphobia/apprehension about going outdoors is getting worse. In addition my mood is still low and motivation is poor, and I seem to be detached from my emotions in a way that makes me feel uncomfortable.
>
> The Solution
> -------------
>
> Might be adding Zoloft (Lustral actually) for its DA reuptake properties. I'm wondering if tianeptine might offset the serotonergic side effects? Does this work in practise? Anyone taken tianeptine with an SSRI or other antidepressant?
>
Zoloft's binding affinity for dopamine is too low at theraputic doses to be of any use. See http://www.preskorn.com/columns/0005.html#fig1 You would prbably be better off using a med such as Wellbutrin or Amantadine

> I skipped last night's dose and I'm feeling back to my normal self already. My mood seems a little brighter and the fog is clearing. Maybe I should come off it altogether?
>
> All opinions welcome.
>
> Q


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