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Re: The Zyprexa story » Phillipa

Posted by yxibow on March 2, 2007, at 23:28:31

In reply to Re: The Zyprexa story » capricorn, posted by Phillipa on March 2, 2007, at 21:44:23

> I know wouldn't touch it with a l0 foot pole. Love Phillipa


Actually it helped me better than Seroquel; they both have weight gain liabilities, and both change lipid profiles, Zyprexa just does more especially at higher doses. My problem with Zyprexa was pseudoparkinsonism which is worse (I think, I have a fair amount of Valium on board now) than Seroquel.


I had shakiness after and during handling power tools and various things that would make my hands eventually shaky, like waving them in the air fast.

I don't know what it would do to me today, when my disorder was worst it lifted my depression within a few days, I didn't need benzodiazepines any more, and the bright lights at night dimmed dramatically. Of course its hard to say now because anything back in those days would be dramatic, now gains or losses are subtle.


As far as the diabetes issue, I certainly don't speak for Lilly; this has been kicking around for quite some time.


In its earliest days, which would have been almost ten years ago, it was pushed by doctors for a lot of things; so was Seroquel as I remember in college by the ** of a psychiatrist who had her fiefdom over the mental health clinic. It was informed consent; the PI did mention weight gain vs. placebo although the amount was probably not significantly noticed because typical trials don't last large numbers of months.


Liability also lies with doctors and visual observations would certainly have set off signals that weight gain was imminent and tests should have been done to determine diabetic potential. I still have those tests done myself, even with Seroquel, at physicals because there are some risks involved.


In the end, regardless of blame, there are few perfect atypicals -- I wish I could combine the good parts of Zyprexa and Seroquel; the rest, well, for me akathisia is too much in general.


There are more atypicals that will probably come on the market by 2010 or so, I'm sure -- they are still early in the pipeline.

Unless you count Invega (paliperidone), the metabolite / patent extension of Risperdal, which is currently over $10 a day in its initial price offerings making it the second highest cost atypical to Clozaril.


Of course if I added up the "real" cost of my 7+ pharmaceutical agent polypharmacy and not the already overpriced copays, who knows what the actual daily cost per day of my "mix" is.


-- tidings

 

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