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Re: What is the longest lasting TCA for sleep?

Posted by psychobot5000 on February 25, 2007, at 11:31:49

In reply to What is the longest lasting TCA for sleep?, posted by starfox on February 24, 2007, at 13:07:09


> I was just wandering what tricyclic AD had the longest half life with regards to sleep?. From what I understand Doxepin Is very good at making you fall asleep but is there another tricyclic that would be better for actually keeping you asleep

I think Doxepin might indeed be the best, but trimipramine/surmontil is very similar, and (I gather) may have a longer half-life in some people(though slightly less sedation from H1 blocking, presumably). So that might be better for a few. Also, Remeron has a similar H1 blocking effect to doxepin, and a longer half-life(something like 33 hrs) than either of them. The disadvantage, I find, was its residual sedation during the day.

Though Remeron is usually thought of as an 'atypical' AD, I believe it is actually a tetracyclic in structure, with some pharmacalogical similarities to TCAs.


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