Posted by halcyondaze on February 20, 2007, at 15:34:30
In reply to Re: Are MAOIs ever ineffective? » halcyondaze, posted by Chairman_MAO on February 20, 2007, at 14:32:24
> Is that study a joke? The full therapeutic dose of tranylcypromine is no less than 0.8mg/kg/day, and can be 1.5-2mg/kg/day. The 60mg/day maximum dose is a fiction. It's really around 120-200mg/day, and any competent psychiatrist knows this.
>
> A non-blinded study of antidepressants is also intrinsically worthless.Agreed. The STAR*D depression trial, which took a large population through several stages of medications, with those deemed non-responsive moving onto the next stage, is fast becoming a classic. All parts were published in the Am J of Psychiatry and unfortunately, many people do not take the time to read the methodology before taking for granted the conclusions drawn in studies such as these. So now the idea of Parnate being the "drug of choice for tx-resistance" is being questioned, due to the dubious methods of the trial.
I personally saw no effect at 60 mg/day and I was at a very low weight for my height then, suffering with anorexia nervosa. As the AN remitted and we got a better idea of what was the depression vs. the anorexia, 60 mg still wasn't enough. Now, at 5'2 and 110 lbs, 120 mg is an ideal dose.
poster:halcyondaze
thread:734115
URL: http://www.dr-bob.org/babble/20070219/msgs/734527.html