Posted by ace on February 16, 2007, at 19:34:59
In reply to Re: Prozac and Nardil ?akston, posted by Larry Hoover on February 16, 2007, at 5:58:54
> > Thanks all.
> >
> > "12 weeks"! And "be careful"!
> >
> > OK. I'll hang in there till around May 10.
> >
> > My VA doc was ready to have me start after only 2 weeks. Gave me Clonodine in case of a serotinon (sp?) syndrome. I don't trust that.
>
> I'm going to disagree with previous posters.!
Twelve weeks would be an abundance of prudence even if you had been on Prozac for an extended period of time; the half-life increases the longer you're on it.This is very true. And, I believe I was being overly prudent, but whenever I here of strong seretonergic agent being used after an MAOI red flags spin around my head.
The half-life of Prozac after one dose is 2 days, with a range of 1-5 days. I have personally seen and read that it is best to wait 12 weeks when starting Nardil after Prozac therapy. However, I have also seen 2 weeks, 5 weeks, 6 weeks, 8 weeks.
There IS variation (sometimes slight) based on the individual biology.
However, you had not even reached a stable plasma concentration level, with but three days of intake. Far from it.
>
> The mathematics is not worth trying to explain, but two weeks washout was more than adequate, in your case. You're three times that already. And, having clonidine on hand, should the symptoms arise, you're golden.
>
> I would not delay initiating the Nardil, were I in your shoes.All the above is correct. However, I urge you to titrate the drug slow. If you EVER suffer serotonin syndrome a drug called Periactin can reverse symptomatology. Worth having on hand.
Finally, before starting see a psychiatrist or doctor (preferably one who is older than 35!)
Cheeeeeers and sorry for any confusion,
Ace.
> Lar
>
poster:ace
thread:733084
URL: http://www.dr-bob.org/babble/20070213/msgs/733384.html