Posted by Larry Hoover on February 10, 2007, at 14:28:27
In reply to Re: holy mackeral laima! » Larry Hoover, posted by laima on February 7, 2007, at 19:49:01
>
> Hi Larry,
>
> The phenomena is currently fascinating to me- I do wonder how common it is or isn't- if no one believes in it, or knows to look for it, they perhaps don't simply recognize it?I suspect it is more common than most doctors will admit. Their treatments just don't do things like that, ya know? Far easier to blame some neurosis or latent expression of somatiform disorder, or some such.
> It makes logical sense to me, that people could build up tolerance to so-called addictive substances, and enter chronic mini-withdrawal states. But I really of course don't know, and lack any bio/chem training to use in trying to figure it out technically.
As we were on quite different classes of drugs, but with a similar progression, it might be an epi-phenomenon, i.e. one not restricted to any one receptor class. I'm certain that under the influence of an exogenous chemical which disturbs any receptor homeostasis, the body will exert potentially increasing efforts to regain control thereof. So little do we know about the complex interplay and feedback among and within receptor-mediated biochemical complexes, we are very vulnerable to hubris. We think we know so very much.....ha!
> >but what happened to us? How is it that continued use of stable doses met with such dramatic loss of drug effects? This was more than tolerance, methinks.
>
> I would LOVE to know.I would love more to know how to prevent it.
> > > I shudder to think about possible consequences of my antidepressant use.
> >
> > I hear you, but what might the consequence of never having used one be?
>
> Yes, I hear you too- but I originally started them as result of rather mundane adolescent crisis, which might better have been addressed by counseling. Regardless, I worry if they've changed my brain, if my brain is impaired from using them? <snip> Maybe not much point for me to worry about this particular question now though.Pragmatically, not much point. However it is that you got to this point, today, it is without dispute that here you are, today. Gotta look forward, eh?
> Whether you choose to resume your painkillers or not- like you say, a person has to do what they have to do. I do wonder if they might not be newly effective again after the break- but then you face the possibility later of a repeat of what already happened. So complicated, I don't envy your decision.
I appreciate very much the understanding and validation you offer me. I'm scared, truthfully. I just started back at a very painful physiotherapy program, and doing it without those meds is, uhhh, challenging. I am exhausted, and we've only just scratched the surface. One day at a time......
> Warmest wishes,
> Laima
>
>Thanks. And back atcha.
Lar
poster:Larry Hoover
thread:730251
URL: http://www.dr-bob.org/babble/20070207/msgs/731618.html