Posted by wmd40 on February 6, 2007, at 6:46:14
In reply to Re: 20 years of imipramine » wmd40, posted by yxibow on February 5, 2007, at 1:48:43
> Life is for living -- its random, unpredictable, and yet amazing that all of our genetic parts manage to work together in any fashion whatsoever if you look at the human body as a system.I know! It's so exquisitely evil, isn't it? If Satan were out sick with the flu and I had to fill in for a couple of days, I don't think I could dream up anything more horrible than life; not just human life, but the whole panoply of creation. Every creature is endowed by its creator with a primordial urge to live and keep on living as long as possible; and just in case a creature catches on to the game, it's also endowed with a drive to reproduce -- not a conscious drive, of course; just an urge to have sex, and the Grand Design takes it from there, so we're guaranteed to be overcrowded and unhappy and eventually somebody's lunch.
But perhaps that's not what you meant. :-)
> So, first of all -- and I know its easier said than done, with MDD, but this is also a place to find solace, and people who are passionate, and to not give up.
Solace is always worth finding, and I really do struggle not to give up.
> If you've lived through 20 years of it, you are probably right that you know the effects of imipramine. I'm not sure about purplish blue colours but the only minor caveat about TCAs is that they have a small risk of Tardive Dyskinesia, lower than most neuroleptics, but higher than SSRIs. However I would definately say that 20 years is fairly tardive for any major effect like that to happen.That's a relief! I think tardive dyskinesia would pretty much put me past my limits.
> Imipramine (which is actually desipramine in the body) has had 50+ years of use and probably couldn't count the patient-years that would add up to in generics as well. In general, though its not an exact science, we know that aggregate patient-years are a predictor of future predictions. So the thousands of patient-years essentially exceed a human lifetime. Its not as forgiving as an SSRI in overdose (please dont), but besides the previous mentioned possibility, sometimes the old ones are the good ones.Thanks. That's reassuring. I guess I should count my blessings. I could be a guinea pig for one of the newer drugs that have no history of long term use at all.
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wmd40
poster:wmd40
thread:729805
URL: http://www.dr-bob.org/babble/20070201/msgs/730274.html