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Re: Parnate and abuse

Posted by naughtypuppy on February 3, 2007, at 10:07:35

In reply to Re: Parnate and abuse, posted by Quintal on February 2, 2007, at 23:23:51

> I abused Parnate too. My pdoc only prescribed 30mg a day and wanted me to reduce it to 10mg a day as a maintenance dose after a month. I was already taking about 80mg a day by that point. Like hal I took it every few hours, like a short acting amphetamine, to keep me energized and motivated throughout the day. The Klonopin acted to make the cocktail like an upper/downer combo and the Lamictal prevented mania and tolerance to the stims I think.

>
> As far as I'm aware the stimulant effect of Parnate isn't mediated by MAO inhibition (it wouldn't matter if you took Parnate as a single morning dose in terms of MAO inhibition since tranylcypromine binds irreversibly to the MAO enzyme for about 30 days - there just isn't enough new MAO produced by the body to influence the antidepressant effect). My own pet theory is that the MAO inhibition potentates the small amount of amphetamine metabolites (methamphetamine and PEA) which are responsible for the euphoric stimulant effects at high doses. It might be nonsense of course, but that's what I suspect might be happening in Parnate abuse.
>
> It would seem likely that there would be such a thing as 'Parnate Psychosis' or something of the like if people were to abuse it in the same way as coke or crystal meth. Is there a ceiling on Parnate euphoria? Do people need to increase the dose indefinitely or does the MAO inhibition help prevent tolerance? Interesting. I should really go back on Parnate...............
>
> Q

That's really interesting. The only time that I had a euphoric feeling was the first 3 weeks at 20mg. after that period and increasing the dosage, I lost a lot of that feeling. It was like a peaceful calm without anxiety that I have only felt a few times in my life.


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