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Re: Zoloft and dopamine reuptake inhibition

Posted by sukarno on January 22, 2007, at 8:46:22

In reply to Re: Zoloft and dopamine reuptake inhibition, posted by linkadge on January 20, 2007, at 15:32:42

With all of the sexual dysfunction that sertraline (Zoloft) causes, I would find it difficult to believe if it had any significant dopamine reuptake blocking properties.

If anything, when you flood the brain with serotonin as is the case with SSRIs via serotonin reuptake inhibition, it tends to antagonise dopamine.

Amoxapine is a dopamine antagonist as far as I know (someone posted here about amoxapine) so it couldn't be a DA reuptake inhibitor.

Tianeptine (Stablon) would be a better bet if you couldn't find remaining supplies of amineptine (Survector). One researcher theorised that tianeptine's antidepressant effect might be more related to a dopaminergic mechanism vis a vis the D2/D3 receptors. Of course it also has been proven to help restore hippocampal volume.

I wouldn't take tianeptine with sertraline (or any other SSRI), since tianeptine accelerates the reuptake of serotonin while sertraline is doing the exact opposite. It just wouldn't make sense to use both, unless the true antidepressant effect of tianeptine lies in its alleged mild dopaminergic action.

Just my $0.02


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poster:sukarno thread:724214
URL: http://www.dr-bob.org/babble/20070119/msgs/725113.html