Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Zoloft and dopamine reuptake inhibition

Posted by halcyondaze on January 20, 2007, at 14:42:24

In reply to Zoloft and dopamine reuptake inhibition, posted by Quintal on January 20, 2007, at 14:19:43

The chart I refer to from the Psychiatry book was exclusively on dopamine reuptake inhibition.

There's another chart with regard to blockade of DA receptors, in which the affinity is as follows:

Amoxapine: approx 5.5
Trimipramine: approx 0.5
Clomipramine: approx 0.5
Remeron: approx 0.2
Serzone: approx 0.2
And less than 0.1: Imiprimine, Amitriptyline, Nortriptyline, Desipramine, Doxepin, Protriptyline. Less than 0.01 is Prozac, Luvox, and Trazodone.

It really depends on what mechanism you're looking at.

These charts have relative potencies at therapeutic dosing ranges but, without explanation as to the exact mechanism of each drug, are very difficult to compare.

> From the receptor affinity database:
> http://kidb.cwru.edu/pdsp.php
>
> Dopamine Transporter Ki (nM) for various substrates mentioned in this thread (range):
>
> Ritalin 21-50
> Adderal no values for any amphetamines
> Zoloft 22-315 (latter value is an outlier; all others similar to Ritalin)
> Wellbutrin 520-950
> Tranylcypromine 5100 (single value)
> Effexor 3070-9300
> Paxil 268-963
>
> It should also be noted that there are a number of pharmakokinetic parameters influencing the relative effect of these meds at this transporter, including dose, molecular weight, bioavailability, first pass metabolism, and CNS uptake, to say nothing of genetic influences. Also, as mentioned, active metabolites are not considered here (but many are listed in the above database, if you know what they are).
>
> Lar


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:halcyondaze thread:724214
URL: http://www.dr-bob.org/babble/20070119/msgs/724510.html