Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Is paroxetine more dual action than venlafaxine ? » linkadge

Posted by Larry Hoover on January 20, 2007, at 13:24:53

In reply to Is paroxetine more dual action than venlafaxine ?, posted by linkadge on January 19, 2007, at 15:31:07

> http://jpet.aspetjournals.org/cgi/content/full/283/3/1305
>
> "Of particular interest were the findings that paroxetine, generally thought of as a selective SERT antagonist, possesses moderately high affinity for the NET and that venlafaxine, which has been described as a "dual uptake inhibitor", possesses weak affinity for the NET"
>
>
> Linkadge

The Ki (concentration units) of paroxetine binding affinity to the norepinephrine transporter is about one-tenth that of venlafaxine, i.e. equal inhibition of the transporter at one-tenth the concentration. Yes, the paper you cite is correct.

Lar

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Larry Hoover thread:724101
URL: http://www.dr-bob.org/babble/20070119/msgs/724457.html